Single Photon Emission Computed Tomography (SPECT)

Single Photon Emission Computed Tomography (SPECT)


Benefits of MicroSPECT Imaging
• Biologically important radiotracers allow multiple applications
• Radiopharmaceuticals for clinical nuclear medicine are available
• Quantitative measurements
• Multiple probes can be imaged simultaneously
• Adaptable to clinic

Ideally Suited For
• Characterizing the stages and progression of a disease process and establishing signature biomarkers
• Assessing the efficacy of standard or experimental treatment modalities in small-animal models of human disease.
• Multimodality imaging with microCT or MRI to combine functional and anatomical information in a single image

Not Suited For
• Anatomical imaging
• Pharmacokinetic studies

• Much lower sensitivity than microPET
• Moderate resolution (~0.5-1.5 mm), but potentially better than microPET
• Radiation dose to animal

A second radiotracer imaging modality, single photon emission computed tomography (SPECT), can achieve similar spatial resolution to PET. SPECT allows simultaneous detection of more than one radionuclide, although sensitivity is significantly lower than with PET. SPECT can be used for measuring perfusion, labeling cells, and for targeting cell-surface receptors and antigens via radiolabeled peptides and antibodies.

Siemens Inveon SPECT-CT_crop InveonMM SPECT
The InveonMM SPECT module contains high-resolution SPECT detectors designed to provide enhanced sensitivity and spatial resolution. Pinhole collimation inserts (0.5-3.0 mm and either single or multiple pinhole) allow the operator to adjust detector magnification and select the optimal resolution, FOV and sensitivity for each SPECT study. Traditional parallel hole collimation is also possible with the Inveon LEAP collimator. This allows for dynamic projection imaging of SPECT tracers. The energy detection range (20-300 keV) provides the capability of imaging virtually any of the SPECT radiotracers in current use, including 99mTc, 111In, 123I and 125I. A newly developed multimodality software package, Inveon Acquisition Workplace, gives the user an integrated control system to run multimodality acquisitions, reconstruct images and review acquisitions. Inveon Research Workplace software allows the fusion of multimodal images, analysis of static, gated and dynamic data. Coupled as it is with the CT module, the Inveon SPECT/CT can provide the user with coregistered SPECT and CT images, melding the powerful functional and anatomic imaging capabilities of these two modalities. In addition, the CT image can be used for attenuation correction of the SPECT image.

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